Colonic mast cell numbers, symptom profile, and mucosal expression of elements of the epithelial barrier in irritable bowel syndrome.
Johanna SundinSofia NordlanderHelene EutameneValerie Alquier-BacquieChristel CartierVassilia TheodorouBoris Le NevéHans TörnblomMagnus SimrénLena ÖhmanPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2019)
There was no evidence of increased infiltration or altered localization of MCs in the colonic mucosa of patients with IBS. These MC characteristics were not linked to global IBS symptoms or mucosal expression of elements of the epithelial barrier. These findings indicate that quantity and location of mucosal MCs are factors not involved in the pathophysiology of IBS.