Insights From Liver-Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR-Agonist Pharmacodynamics in Humans.

Mirko E MinnitiMatteo PedrelliLise-Lotte VedinAnne-Sophie DelbèsRaphaël G P DenisKatariina ÖörniClaudia SalaChiara PirazziniDivya ThiagarajanHarri J NurmiMarkus GrompeKevin MillsPaolo GaragnaniEwa C S EllisStephen C StromSerge H LuquetElizabeth M WilsonJohn BialKnut R SteffensenPaolo Parini

Published in: Hepatology (Baltimore, Md.) (2020)

LHM represent an interesting translatable model of human hepatic and lipoprotein metabolism. Because several metabolic parameters displayed donor dependency, LHM may also be used in studies for personalized medicine.

Keyphrases

low density lipoprotein
endothelial cells
induced pluripotent stem cells
high fat diet induced
pluripotent stem cells
monoclonal antibody
type diabetes
adipose tissue
metabolic syndrome
skeletal muscle
wild type