The Emergence and Impact of the M1 UK Lineage on Invasive Group A Streptococcus Disease in Aotearoa New Zealand.
Anna VestyXiaoyun RenPrachi SharmaNatalie LorenzThomas ProftAllan HardakerChristina StraubJulie MorganAudrey TiongAnneka AndersonRachel H WebbJulie BennettPhilip E CarterNicole J MorelandPublished in: Open forum infectious diseases (2024)
M1 UK is associated with current surges in invasive infection globally, partly due to increased production of superantigen streptococcal pyrogenic exotoxin A. We show that M1 UK is now the dominant invasive emm 1 lineage in Aotearoa New Zealand and is genomically related to community infections, suggesting that measures that effectively prevent group A Streptococcus pharyngitis in children could reduce invasive disease.