Proteomic Pathways across Ejection Fraction Spectrum in Heart Failure: an EXSCEL Substudy.
Anthony E PetersMaggie NguyenJennifer B GreenEwan R PearsonJohn BuseHarald SourijAdrian F HernandezNaveed SattarRury R HolmanRobert J MentzSvati H ShahPublished in: medRxiv : the preprint server for health sciences (2023)
In this HF substudy of a large clinical trial of people with T2DM, we found that serum levels of most proteins across multiple biologic domains were similar between HFmrEF and HFpEF. HFmrEF may be more biologically similar to HFpEF than HFrEF, and specific related biomarkers may offer unique data on prognosis and pharmacotherapy modification with variability by EF.
Keyphrases
- ejection fraction
- heart failure
- clinical trial
- aortic stenosis
- acute heart failure
- rheumatoid arthritis
- electronic health record
- left ventricular
- big data
- smoking cessation
- phase ii
- study protocol
- double blind
- label free
- adipose tissue
- randomized controlled trial
- deep learning
- skeletal muscle
- aortic valve
- data analysis