Response to Tembhre et al.: 'Enhanced expression of angiotensin-converting enzyme 2 in psoriatic skin and its upregulation in keratinocytes by interferon-γ: implication of inflammatory milieu in skin tropism of SARS-CoV-2'.
Jeffrey R GehlhausenChristine J KoWilliam E DamskyPublished in: The British journal of dermatology (2021)
We recently read the research letter 'Enhanced expression of ACE2 in psoriatic skin and its upregulation in keratinocytes by interferon-gamma: Implication of inflammatory milieu in skin tropism of SARS-CoV-2' by Tembhre and colleagues with great interest. In their manuscript, the authors describe that while the expression patterns of Angiotensin Converting Enzyme 2 (ACE2) and other SARS-CoV-2 co-factors have been characterized in the skin during homeostatic conditions, they have not been examined in the state of pathogenic inflammation.
Keyphrases
- angiotensin converting enzyme
- sars cov
- poor prognosis
- angiotensin ii
- wound healing
- soft tissue
- oxidative stress
- respiratory syndrome coronavirus
- long non coding rna
- rheumatoid arthritis
- binding protein
- dendritic cells
- cell proliferation
- ankylosing spondylitis
- disease activity
- signaling pathway
- systemic lupus erythematosus