Imaging of αvβ3 integrin expression in experimental myocardial ischemia with [68Ga]NODAGA-RGD positron emission tomography.

Maria GrönmanMiikka TarkiaTuomas KiviniemiPaavo HalonenAntti KuivanenTimo SavunenTuula TolvanenJarmo TeuhoMeeri KäkeläOlli MetsäläMikko PietiläPekka SaukkoSeppo Ylä-HerttualaJuhani KnuutiAnne RoivainenAntti Saraste

Published in: Journal of translational medicine (2017)

Cardiac [68Ga]NODAGA-RGD PET demonstrates increased myocardial αvβ3 integrin expression after induction of flow-limiting coronary stenosis in pigs. Localization of [68Ga]NODAGA-RGD uptake indicates that it reflects αvβ3 integrin expression associated with repair of recent myocardial injury.

Keyphrases

pet ct
positron emission tomography
poor prognosis
computed tomography
left ventricular
coronary artery disease
binding protein
pet imaging
high resolution
coronary artery
long non coding rna
cell migration
cell adhesion
mass spectrometry
ejection fraction