Study protocol for the multicentre cohorts of Zika virus infection in pregnant women, infants, and acute clinical cases in Latin America and the Caribbean: the ZIKAlliance consortium.
Vivian I Avelino-SilvaPhilippe MayaudAdriana TamiMaria C MirandaKerstin D RosenbergerNeal AlexanderLuis NaculAluisio SeguradoMoritz PohlSarah BethencourtLuis A VillarIsabelle F T VianaRenata RabelloCarmen SoriaSilvia P SalgadoEduardo GotuzzoMaría G GuzmánPedro A MartínezHugo López-GatellJennifer Hegewisch-TaylorVictor H Borja-AburtoCesar GonzalezEduardo M NettoPaola M Saba VillarroelBruno HoenPatrícia BrasilErnesto T A MarquesBarry RockxMarion KoopmansXavier de LamballerieThomas Jaenischnull nullPublished in: BMC infectious diseases (2019)
Results of these large cohort studies will provide better risk estimates for birth defects and other developmental abnormalities associated with ZIKV infection including possible co-factors for the variability of risk estimates between other countries and regions. Additional outcomes include incidence and transmission estimates of ZIKV during and after pregnancy, characterization of short and long-term clinical course following infection and viral kinetics of ZIKV. STUDY REGISTRATIONS: clinicaltrials.gov NCT03188731 (PW cohort), June 15, 2017; clinicaltrials.gov NCT03393286 (CH cohort), January 8, 2018; clinicaltrials.gov NCT03204409 (NH cohort), July 2, 2017.