Isolation and Structure Elucidation of Cembranoids from a Dongsha Atoll Soft Coral Sarcophyton stellatum.
Atallah F AhmedYi-Wei ChenChiung-Yao HuangYen-Ju TsengChi-Chen LinChang-Feng DaiYang-Chang WuJyh-Horng SheuPublished in: Marine drugs (2018)
Six new polyoxygenated cembrane-based diterpenoids, stellatumolides A⁻C (1⁻3), stellatumonins A and B (4 and 5), and stellatumonone (6), were isolated together with ten known related compounds (7⁻16) from the ethyl acetate (EtOAc) extract of soft coral Sarcophyton stellatum. The structures of the new compounds were established by extensive spectroscopic analyses, including 1D and 2D nuclear magnetic resonance (NMR) spectroscopy and data comparison with related structures. Compounds 8 and 14 were isolated from a natural source for the first time. The isolated metabolites were shown to be not cytotoxic against a limited panel of cancer cells. Compound 9 showed anti-inflammatory activity by reducing the expression of proinflammatory cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) proteins in lipopolysaccharide (LPS)-stimulated mouse leukaemic monocyte macrophage (RAW 264.7) cells.
Keyphrases
- nitric oxide synthase
- nitric oxide
- magnetic resonance
- inflammatory response
- high resolution
- poor prognosis
- induced apoptosis
- cell cycle arrest
- dendritic cells
- oxidative stress
- anti inflammatory
- adipose tissue
- endothelial cells
- electronic health record
- lps induced
- cell proliferation
- machine learning
- magnetic resonance imaging
- signaling pathway
- ionic liquid
- big data
- binding protein
- artificial intelligence
- endoplasmic reticulum stress
- long non coding rna