Oxidative stress enhances the expression of IL-33 in human airway epithelial cells.
Hiroyuki AizawaAkira KoaraiYutaka ShishikuraSatoru YanagisawaMutsuo YamayaHisatoshi SugiuraTadahisa NumakuraMitsuhiro YamadaTomohiro IchikawaNaoya FujinoMasafumi NodaYoshinori OkadaMasakazu IchinosePublished in: Respiratory research (2018)
These results demonstrate that oxidative stress involves in the expression of IL-33 in airway epithelial cells via MAPK signal pathway and it augments IL-33 expression during viral infection. This mechanism may participate in the regulation of IL-33 expression in airway epithelial cells in COPD and the viral-induced exacerbations. Modulation of this pathway could become a therapeutic target for viral-induced exacerbations of COPD.