Impact of chrysin on the molecular mechanisms underlying diabetic complications.
Tahereh FarkhondehSaeed SamarghandianBabak RoshanravanPublished in: Journal of cellular physiology (2019)
Diabetes mellitus is a chronic metabolic disorder, resulting in high morbidity and mortality worldwide. Neuropathy, ocular diseases, kidney diseases, and cardiovascular disease are common complications of diabetes that threats the patient's life. Chrysin (CH), a natural flavonoid, has several pharmacological effects, including antioxidant, antiapoptotic, anti-inflammatory, and anticancer. Strong scientific documents indicated that chrysin may be effective for preventing and treating complications of diabetes in experimental models. The present study was designed to review the association between chrysin administration and diabetes complications by focusing on the possible molecular pathway. The findings indicate that chrysin has protective effects against diabetes outcomes by modulating oxidative stress, inflammation, and apoptosis in animal models. However, more clinical trial study should be done to clear the protective effects of chrysin in diabetic patients.
Keyphrases
- cardiovascular disease
- oxidative stress
- type diabetes
- glycemic control
- clinical trial
- risk factors
- anti inflammatory
- dna damage
- randomized controlled trial
- ischemia reperfusion injury
- diabetic rats
- endoplasmic reticulum stress
- coronary artery disease
- cardiovascular risk factors
- cardiovascular events
- insulin resistance
- cell death
- phase ii
- open label
- ionic liquid