Characterization of the expression and immunological impact of the transcriptional activator CREB in renal cell carcinoma.

Michael FriedrichChristine StoehrSimon Jasinski-BergnerArndt HartmannSven WachBernd WullichAndré StevenBarbara Seliger

Published in: Journal of translational medicine (2020)

An interaction of CREB with the HLA-G promoter could be validated in RCC cell lines. Thus, for the first time the expression of CREB and its interaction with the HLA-G in human RCCs has been shown, which might be of clinical relevance.

Keyphrases

renal cell carcinoma
poor prognosis
gene expression
endothelial cells
transcription factor
dna methylation
long non coding rna
induced pluripotent stem cells
oxidative stress
immune response
toll like receptor