Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications.
Theresa KisselS ReijmL M SlotM CavallariC M WortelR D VergroesenG Stoeken-RijsbergenJ C KwekkeboomArieke Suzanna Berendina KampstraEwn LevarhtJ W DrijfhoutH BangK M BongerGmc JanssenP A van VeelenThomas Wj HuizingaH U SchererM RethRené E M ToesPublished in: Annals of the rheumatic diseases (2020)
Our study illustrates that AMPA exhibit a high cross-reactivity towards at least two PTMs indicating that their recognition pattern is not confined to one type of modification. Furthermore, our data show that CP-reactive B cells are not only activated by citrullinated, but also by carbamylated and/or acetylated antigens. These data are vital for the understanding of the breach of B-cell tolerance against PTM-antigens and the possible contribution of these antigens to RA-pathogenesis.