Establishing minimally important differences for cardiac MRI endpoints in pulmonary arterial hypertension.
Samer AlabedPankaj GargFaisal AlandejaniKrit DwivediAhmed MaiterKavita KarunasaagararSmitha RajaramCatherine HillSteven ThomasRebecca GosslingMichael SharkeyMahan SalehiJim M WildLisa WatsonAbdul G HameedAthanasios CharalampopoulosHaiping LuAlex RothmanAlfred Arthur Roger ThompsonCharlie A ElliotNeil HamiltonChristopher S JohnsIain ArmstrongRobin CondliffeRob J van der GeestAndrew J SwiftDavid G KielyPublished in: The European respiratory journal (2023)
This study establishes clinically relevant CMR MIDs for how a patient feels, functions or survives in response to PAH treatment. These findings provide further support for the use of CMR as a clinically relevant clinical outcome measure and will aid trial-size calculations for studies using CMR.
Keyphrases
- pulmonary arterial hypertension
- pulmonary artery
- pulmonary hypertension
- magnetic resonance imaging
- clinical trial
- study protocol
- case report
- molecular dynamics
- left ventricular
- contrast enhanced
- randomized controlled trial
- molecular dynamics simulations
- coronary artery
- polycyclic aromatic hydrocarbons
- replacement therapy