BCL11B expression in hepatocellular carcinoma relates to chemosensitivity and clinical prognosis.

Hiroyuki AbeKenya KamimuraShujiro OkudaYu WatanabeJun InoueYutaka AoyagiToshifumi WakaiRyo KominamiShuji Terai

Published in: Cancer medicine (2023)

Our results indicated that overexpression of BCL11B amplifies GATA6 expression in hepatocellular carcinoma in vitro and in vivo that leads to anti-apoptotic signal activation, and induces resistance to chemotherapy, which influenced the postoperative prognosis.

Keyphrases

poor prognosis
transcription factor
cell death
patients undergoing
binding protein
squamous cell carcinoma
radiation therapy
locally advanced