Lipid metabolism impairment in patients with sepsis secondary to hospital acquired pneumonia, a proteomic analysis.
Narendra Kumar SharmaBianca Lima FerreiraAlexandre Keiji TashimaMilena Karina Colo BrunialtiRicardo Jose Soares TorquatoAntonio BafiMurillo AssuncaoLuciano Cesar Pontes AzevedoReinaldo SalomãoPublished in: Clinical proteomics (2019)
Proteomic analysis pointed to impairment of lipid metabolism as a major change in septic patients secondary to HAP, which was further validated by the reduced levels of cholesterol moieties and apolipoproteins in plasma. Our results stress the involvement of lipids in the pathogenesis of sepsis, which is in accordance with previous reports supporting the role of lipid moieties in pathogen toxin clearance and in modulating inflammatory responses.
Keyphrases
- acute kidney injury
- end stage renal disease
- fatty acid
- intensive care unit
- ejection fraction
- newly diagnosed
- escherichia coli
- chronic kidney disease
- septic shock
- peritoneal dialysis
- adverse drug
- signaling pathway
- emergency department
- patient reported outcomes
- low density lipoprotein
- acute care
- electronic health record
- drug induced