The big five personality traits are associated, although indirectly, with the intention to be vaccinated. Compared with similar studies on the effects of the big five on COVID-19-related outcomes, we found slightly higher proportions of explained variance in conspiracy beliefs and significantly higher explained variance in vaccination intention. In order to increase the willingness to be vaccinated, targeted and nationwide uniform information measures should be provided addressing feelings of security, of not being excluded, and the activation of critical reasoning.