Prenatal Nicotine Exposure Raises Male Blood Pressure via FTO-Mediated NOX2/ROS Signaling.
Bailin LiuLiang XiaYong LiSiyi JiangWansu YuLubo ZhangXuesi M ShaoZhice XuDaLiao XiaoPublished in: Hypertension (Dallas, Tex. : 1979) (2023)
This study uncovers a new mechanism: m6A demethylase FTO-mediated epigenetic upregulation of vascular NOX2 signaling in CINA-induced hypertensive phenotype. This insight could lead to a therapeutic target for preventing and treating developmental hypertension programming.