Reasons and Determinants of BoNT-A Treatment Discontinuation in Patients Living with Spasticity: A 10-Year Retrospective Analysis.
Nicoletta CinoneLuigi SantoroStefania SpinaSalvatore FacciorussoMarco BattagliaAlessio BaricichPasqua MarcogiuseppeAndrea SantamatoPublished in: Toxins (2022)
The main reasons for discontinuation are related to logistic issues (due to distance or the absence of an adequate caregiver) and surgical interventions for spasticity, including intrathecal baclofen. It is crucial to identify possible predictors of discontinuation to improve the effectiveness of a multidisciplinary management. The study confirms the crucial role of rehabilitation and caregivers in achieving better long-term outcomes.
Keyphrases
- end stage renal disease
- spinal cord injury
- ejection fraction
- newly diagnosed
- chronic kidney disease
- randomized controlled trial
- botulinum toxin
- upper limb
- systematic review
- palliative care
- peritoneal dialysis
- physical activity
- prognostic factors
- cerebral palsy
- quality improvement
- children with cerebral palsy
- smoking cessation
- drug induced