Human Interleukin-34 facilitates microglia-like cell differentiation and persistent HIV-1 infection in humanized mice.

Saumi MathewsAmanda Branch WoodsIkumi KatanoEdward MakarovMidhun B ThomasHoward E GendelmanLarisa Y PoluektovaMamoru ItoSanthi Gorantla

Published in: Molecular neurodegeneration (2019)

This humanized microglia mouse reflected human HIV-1 infection in its known principal reservoir and showed the development of disease-specific innate immune inflammatory and neurotoxic responses mirroring what can occur in an infected human brain.

Keyphrases

endothelial cells
innate immune
induced pluripotent stem cells
inflammatory response
pluripotent stem cells
antiretroviral therapy
neuropathic pain
oxidative stress
spinal cord
metabolic syndrome
spinal cord injury
skeletal muscle