Detailed Transcriptional Landscape of Peripheral Blood Points to Increased Neutrophil Activation in Treatment-Naïve Inflammatory Bowel Disease.

Simonas JuzenasMatthias HübenthalCarl Mårten LindqvistRobert KruseTim Alexander Steiert Frauke DegenhardtDominik SchulteSusanna NikolausSebastian ZeissigDaniel BergemalmSven AlmerHenrik HjortswangFrancesca Bressonull nullNina StrüningJuozas KupcinskasAndreas KellerWolfgang LiebPhilip RosenstielStefan SchreiberMauro D'AmatoJonas HalfvarsonGeorg Hemmrich-StanisakAndre Franke

Published in: Journal of Crohn's & colitis (2022)

Immune dysregulation seen in peripheral blood transcriptomes of treatment-naïve IBD patients is mainly driven by neutrophil activation.

Keyphrases

peripheral blood
end stage renal disease
chronic kidney disease
newly diagnosed
ejection fraction
single cell
transcription factor
peritoneal dialysis
patient reported