Intracerebral haemorrhage in patients taking different types of oral anticoagulants: a pooled individual patient data analysis from two national stroke registries.
Bernhard Matthias SiepenElisabeth ForfangMattia BrancaBoudewijn DropMadlaine MuellerMartina Béatrice GoeldlinMira KatanPatrik MichelCarlo CeredaFriedrich MedlinNils PetersSusanne RenaudJulien NiederhauserEmmanuel CarreraTimo KahlesGeorg KägiManuel BologneseStephan SalmenMarie-Luise MonoAlexandros A PolymerisSusanne WegenerWerner Josef Z'GraggenJohannes KaesmacherMichael SchaererBiljana RodicEspen Saxhaug KristoffersenKristin Tveitan LarsenTorgeir Bruun WyllerBastian VolbersThomas Raphael MeinelMarcel ArnoldStefan T EngelterLeo H BonatiUrs FischerOle Morten RønningDavid Julian SeiffgePublished in: Stroke and vascular neurology (2024)
The spectrum of anticoagulation-associated ICH changed over time. Compared with patients without prior anticoagulation, prior VKA treatment and prior DOAC treatment were independently associated with lower odds of favourable outcome and higher odds of mortality at 3 months. Specific reversal agents unavailable during the study period might improve outcomes of DOAC-associated ICH in the future.
Keyphrases
- atrial fibrillation
- end stage renal disease
- ejection fraction
- newly diagnosed
- data analysis
- chronic kidney disease
- clinical trial
- type diabetes
- patient reported outcomes
- randomized controlled trial
- coronary artery disease
- quality improvement
- cardiovascular events
- patient reported
- insulin resistance
- risk factors
- smoking cessation
- replacement therapy
- phase iii