The Association Between Fennel Extract, Serum Lipid Profile, and Leptin Receptor Expression.

Obesity is one of the most serious challenges of our era, with significant health consequences. Researchers have focused on some natural ingredients and herbal extracts. The current study aimed to investigate the association between Foeniculum vulgar (fennel) extracts and body weight, lipid profile, and leptin. After treatment of fennel, leptin receptor protein expression was increased in all groups, while serum leptin didn't change significantly. A significant decrease was observed in the cholesterol, triglycerides and LDL in some doses of fennel. Serum HDL was increased significantly in a dose of 100 mg/kg/day. So fennel extract can decrease the lipid profile by changing the expression of the leptin receptor.