Long noncoding RNA PVT1: A highly dysregulated gene in malignancy.
Seyedeh Morvarid NeishabouriMir Davood OmraniMohammad TaheriPublished in: Journal of cellular physiology (2019)
Recent studies have verified the contribution of several long noncoding RNAs (lncRNAs) in the carcinogenesis. Among the highly acknowledged lncRNAs is the human homolog of the plasmacytoma variant translocation gene, which is called PVT1. PVT1 resides near Myc oncogene and regulates the oncogenic process through modulation of several signaling pathways, such as TGF-β, Wnt/ β-catenin, PI3K/AKT, and mTOR pathways. This lncRNA has a circular form as well. Expression analyses and functional studies have appraised the oncogenic roles of PVT1 and circPVT1. Experiments in several cancer cell lines have shown that PVT1 silencing suppresses cancer cell proliferation, whereas its overexpression has the opposite effect. Its silencing has led to the accumulation of cells in the G0/G1 phase and diminished the number of cells in the S phase. Moreover, genome-wide association studies have signified the role of single nucleotide polymorphisms of this lncRNA in conferring risk of lymphoma in different populations. In the current study, we have summarized recent data about the role of PVT1 and circPVT1 in the carcinogenesis process.
Keyphrases
- cell proliferation
- pi k akt
- cell cycle arrest
- long noncoding rna
- signaling pathway
- induced apoptosis
- papillary thyroid
- transcription factor
- genome wide identification
- cell cycle
- cell death
- case control
- epithelial mesenchymal transition
- endothelial cells
- poor prognosis
- copy number
- genome wide
- long non coding rna
- squamous cell
- genome wide analysis
- stem cells
- endoplasmic reticulum stress
- diffuse large b cell lymphoma
- electronic health record
- machine learning
- data analysis