Extracellular vesicles derived from human ES-MSCs protect retinal ganglion cells and preserve retinal function in a rodent model of optic nerve injury.
Seyedeh-Zahra SeyedrazizadehSara PoostiAbdoreza NazariMehdi AlikhaniFaezeh ShekariFarzad PakdelKoorosh ShahpasandLeila SatarianHossein BaharvandPublished in: Stem cell research & therapy (2020)
Our findings propose that human ES-MSC EVs, as an off-the-shelf and cell-free product, may have profound clinical implications in treating injured RGCs and degenerative ocular disease. Moreover, the possible mechanisms of human ES-MSC EV are related to the rescue of tauopathy process of RGC degeneration.
Keyphrases
- endothelial cells
- optic nerve
- induced pluripotent stem cells
- pluripotent stem cells
- optical coherence tomography
- induced apoptosis
- mesenchymal stem cells
- autism spectrum disorder
- oxidative stress
- cell proliferation
- cell death
- bone marrow
- intellectual disability
- cell cycle arrest
- circulating tumor cells
- circulating tumor