Clinical, endoscopic and safety placebo rates in induction and maintenance trials of Crohn's disease: Meta-analysis of Randomised controlled trials.
Ahmed AlmradiRocio SedanoMalcolm HoganG Y ZouJohn K MacDonaldClaire E ParkerJurij HanzelEileen CrowleySiddharth SinghGeert D'HaensWilliam J SandbornBrian G FeaganChristopher MaVipul JairathPublished in: Journal of Crohn's & colitis (2021)
Placebo remission and response rates in CD trials vary according to the phase of the trial, endpoint assessed and by induction or maintenance design. These contemporary estimates will help to inform future CD trial design.