Efficacy of a two-test protocol for achieving a therapeutic response to clopidogrel prior to elective endovascular intracranial aneurysm treatment and an 'induced' postoperative hyper-response.
Yasha KadkhodayanJosser E Delgado AlmandozJennifer L FeaseAnna M MilnerJill M ScholzMaximilian MulderPublished in: Journal of neurointerventional surgery (2016)
The protocol achieves in-range preoperative PRU by the second test in almost nine of 10 patients. Nearly two-thirds of patients exhibited postoperative hyper-response to clopidogrel. Out-of-range PRU was not associated with thromboembolic or hemorrhagic neurological complications in this cohort of patients with actively managed P2Y12 inhibition.
Keyphrases
- end stage renal disease
- patients undergoing
- newly diagnosed
- ejection fraction
- randomized controlled trial
- peritoneal dialysis
- acute coronary syndrome
- prognostic factors
- percutaneous coronary intervention
- coronary artery
- coronary artery disease
- patient reported outcomes
- oxidative stress
- diabetic rats
- blood brain barrier
- brain injury
- optic nerve