SARS-CoV-2-infected human airway epithelial cell cultures uniquely lack interferon and immediate early gene responses caused by other coronaviruses.

Ying WangMelissa ThalerClarisse Salgado-BenvindoNathan LyAnouk A LeijsDennis K NinaberPhilip M HansbroFia BoedijonoMartijn J van HemertPieter S HiemstraAnne M van der DoesAlen Faiz

Published in: Clinical & translational immunology (2024)

Our results demonstrate a previously unknown suppression of a host response gene set by SARS-CoV-2 and confirm a difference in interferon-related gene expression between highly pathogenic and low pathogenic coronaviruses.

Keyphrases

sars cov
gene expression
respiratory syndrome coronavirus
genome wide
copy number
dendritic cells
endothelial cells
dna methylation
genome wide identification
induced pluripotent stem cells
immune response
pluripotent stem cells
transcription factor