Identification of immune-activating metabolite for enhancing T cell therapy of cancer.
Boyi CongZenghui CuiXue-Tao CaoPublished in: Cancer communications (London, England) (2021)
In this Research Highlight, we summarized the results from a study by Wu et al. published in Nature Cell Biology which uncovered that asparagine (Asn), a non-essential amino acid in mammalians, is able to enhance the TCR-mediated activation and efficacy of CD8+ T cells towards tumour through lymphocyte-specific protein tyrosine kinase (LCK) signalling. This study provides insights into the physiological function of Asn in T cell activation and effector functions, showing the encouraging possibility of key metabolites for empowering cancer immunotherapy.
Keyphrases
- tyrosine kinase
- amino acid
- epidermal growth factor receptor
- regulatory t cells
- papillary thyroid
- single cell
- cell therapy
- ms ms
- signaling pathway
- dendritic cells
- randomized controlled trial
- stem cells
- peripheral blood
- systematic review
- squamous cell
- squamous cell carcinoma
- binding protein
- protein protein
- childhood cancer
- smoking cessation
- bioinformatics analysis