Thrombin Generation Is Associated With Extracellular Vesicle and Leukocyte Lipid Membranes in Atherosclerotic Cardiovascular Disease.
Majd B ProttyVictoria J TyrrellKeith Allen-RedpathShin SoyamaAli A HajeyahDaniela CostaAnirban ChoudhuryRito MitraAmal SharmanParveen YaqoobPeter Vincent JenkinsZaheer YousefPeter W CollinsValerie B O'DonnellPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
The aPL membrane of EV supports an elevated level of thrombin generation in patient plasma in ASCVD. Leukocytes may also play a role although the platelet membrane did not seem to contribute. Targeting EV formation/clearance and developing strategies to prevent the aPL surface of EV interacting with coagulation factors represents a novel antithrombotic target in ASCVD.