Decoding a gene expression program that accompanies the phenotype of sporadic and basal cell nevus syndrome-associated odontogenic keratocyst.
Eleni-Marina KalogirouSpyros FoutadakisMarianna A KoutsiGiannis VatsellasDimitrios VlachodimitropoulosVassilis PetsinisAlexandra SklavounouMarios AgelopoulosKonstantinos I TosiosPublished in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2022)
The odontogenic keratocyst transcriptomic profile is characterized by a prominent epidermal and dental epithelial fate, a repressed dental mesenchyme fate combined with deregulated extracellular matrix organization, and enhanced stemness gene signatures. Thus, we propose a developed epidermis-like phenotype in the odontogenic keratocyst suprabasal epithelial cells, established in parallel to a significant upregulation of marker genes related to embryonic stem cells and cellular reprogramming.
Keyphrases
- extracellular matrix
- embryonic stem cells
- genome wide
- gene expression
- single cell
- dna methylation
- oral health
- genome wide identification
- stem cells
- quality improvement
- epithelial mesenchymal transition
- cell therapy
- rna seq
- copy number
- late onset
- cell proliferation
- poor prognosis
- signaling pathway
- case report
- genome wide analysis
- wound healing
- early onset