CD11c expression in chronic lymphocytic leukemia revisited, related with complications and survival.
Elif Gülsüm ÜmitM BaysalY DurmusA M DemirPublished in: International journal of laboratory hematology (2017)
CD11c, expressed not only in Hairy cell leukemia but also in dendritic cells, macrophages and monocytes is a differentiation marker for inflammation. Prolonged inflammation in the microenvironment of CLL cells may cause a susceptibility to autoimmune disorders and secondary tumors in CLL, in this way, an increase in mortality.
Keyphrases
- chronic lymphocytic leukemia
- dendritic cells
- oxidative stress
- induced apoptosis
- poor prognosis
- immune response
- risk factors
- cell cycle arrest
- stem cells
- single cell
- acute myeloid leukemia
- nk cells
- regulatory t cells
- cardiovascular events
- multiple sclerosis
- cell therapy
- bone marrow
- cell death
- peripheral blood
- coronary artery disease
- mesenchymal stem cells