Zuo Jin Wan Reverses the Resistance of Colorectal Cancer to Oxaliplatin by Regulating the MALAT1/miR-200s/JNK Signaling Pathway.

Zhenzhen Wei Jing Zhou Hao Yu Yunzhou Pu Yuelei Cheng Yi Zhang Qing Ji Huirong Zhu

Published in: Evidence-based complementary and alternative medicine : eCAM (2022)

Our study identified that MALAT1 promotes colorectal cancer resistance to oxaliplatin by reducing the miR-200s expression. ZJW may reverse chemoresistance by inhibiting the expression of MALAT1 and regulating the miR-200s/JNK pathway, providing an experimental basis for the clinical application of ZJW in relieving chemotherapy resistance.

Keyphrases

signaling pathway
long non coding rna
poor prognosis
cell proliferation
long noncoding rna
induced apoptosis
pi k akt
cell death
epithelial mesenchymal transition
binding protein
oxidative stress
radiation therapy
endoplasmic reticulum stress