Post Hoc Analysis of Lorlatinib Intracranial Efficacy and Safety in Patients With ALK -Positive Advanced Non-Small-Cell Lung Cancer From the Phase III CROWN Study.

Benjamin J Solomon Todd M Bauer Sai-Hong Ignatius OuGeoffrey LiuHidetoshi Hayashi Alessandra BearzKonstantin PenkovYi-Long Wu Oscar ArrietaJacek JassemAnna M CalellaGerson PeltzAnna PolliHolger ThurmTony S K Mok

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2022)

-positive non-small-cell lung cancer with or without brain metastases at baseline. Half of all CNS AEs resolved without intervention or with lorlatinib dose modification.

Keyphrases

advanced non small cell lung cancer
phase iii
brain metastases
epidermal growth factor receptor
small cell lung cancer
open label
clinical trial
randomized controlled trial
phase ii
blood brain barrier
placebo controlled
study protocol
optical coherence tomography