Clinical characteristics, treatment patterns and adherence in patients with asthma on multiple inhaler triple therapy: a review of findings.
Mario CazzolaLuigino CalzettaBarbara RinaldiVito De NovellisRogliani PaolaMaria Gabriella MateraPublished in: Expert review of respiratory medicine (2023)
The use of MITT is not very frequent in asthma patients, although it improves lung function and reduces the incidence of severe exacerbations. This may be due to existing concerns about using different devices on adherence and persistence to treatment, with a negative influence on outcomes, and to the fear that the patient will discontinue ICS/LABA but not LAMA. Nevertheless, although the current trend favors the SITT approach, some physicians may be induced to prescribe MITT over SITT because it allows the titration of individual components of triple therapy to be increased or decreased. Therefore, there is an evident need for pragmatic real-life studies to document when to prefer SITT and when MITT should be used.
Keyphrases
- lung function
- chronic obstructive pulmonary disease
- cystic fibrosis
- air pollution
- end stage renal disease
- primary care
- newly diagnosed
- ejection fraction
- randomized controlled trial
- stem cells
- combination therapy
- type diabetes
- study protocol
- clinical trial
- prognostic factors
- mesenchymal stem cells
- metabolic syndrome
- early onset
- adipose tissue
- bone marrow
- insulin resistance
- endothelial cells
- weight loss
- duchenne muscular dystrophy