A Systematic Review on Dementia and Translocator Protein (TSPO): When Nuclear Medicine Highlights an Underlying Expression.
Miriam ConteMaria Silvia De FeoFerdinando CoricaJoana GoricaMarko Magdi Abdou SidrakFlaminia De CristofaroLuca FilippiMaria RicciGiuseppe De VincentisViviana FrantellizziPublished in: Biomolecules (2023)
C. An emerging limitation to this however is that neuroinflammation involves all of the brain which inhibits the possibility of detecting a slight inflammation status change in patients. A partial solution to this is using the cerebellum as a reference region and developing higher TSPO affinity tracers. Moreover, it is necessary to consider the presence of distomers and racemic compounds interfering with pharmacological tracers' effects and increasing the noise ratio in images.
Keyphrases
- end stage renal disease
- cognitive impairment
- ejection fraction
- pet imaging
- poor prognosis
- newly diagnosed
- prognostic factors
- chronic kidney disease
- deep learning
- binding protein
- traumatic brain injury
- air pollution
- mild cognitive impairment
- resting state
- white matter
- lipopolysaccharide induced
- multiple sclerosis
- patient reported outcomes
- brain injury
- inflammatory response
- lps induced
- positron emission tomography
- subarachnoid hemorrhage
- pet ct