Accelerated versus standard initiation of renal replacement therapy for critically ill patients with acute kidney injury: a systematic review and meta-analysis of RCT studies.
Heng-Chih PanYing-Ying ChenI-Jung TsaiChih-Chung ShiaoTao-Min HuangChieh-Kai ChanHung-Wei LiaoTai-Shuan LaiYvonne ChuehVin-Cent WuYung-Ming ChenPublished in: Critical care (London, England) (2021)
In this meta-analysis, critically ill patients with severe AKI would benefit from accelerated RRT initiation regarding all-cause mortality and being eventually free of dialysis only if they were surgical ICU patients or if they underwent CRRT treatment. However, the risk of dialysis dependence was increased in the accelerated RRT group when those patients used non-CRRT modality or had high SOFA scores. All the literatures reviewed in this study were highly heterogeneous and potentially subject to biases. Trial registration CRD42020201466, Sep 07, 2020. https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=201466 .
Keyphrases
- end stage renal disease
- acute kidney injury
- chronic kidney disease
- peritoneal dialysis
- systematic review
- ejection fraction
- newly diagnosed
- cardiac surgery
- prognostic factors
- clinical trial
- intensive care unit
- randomized controlled trial
- study protocol
- early onset
- patient reported outcomes
- meta analyses
- smoking cessation
- phase iii
- case control
- double blind