Advanced adenoid cystic carcinoma (ACC) is featured by SWI/SNF chromatin remodeling complex aberrations.

Beata JagielskaElzbieta SarnowskaNataliia RusetskaIga JancewiczMonika DurzynskaSzymon KubalaEwa ChmielikPiotr PaulTomasz RutkowskiTomasz J SarnowskiJanusz A Siedlecki

Published in: Journal of cancer research and clinical oncology (2018)

Our study indicated that ACC features aberrant expression of genes controlling chromatin status and structure. We found that the balance between SWI/SNF classes is moved towards the BRM ATPase-containing complex in ACC. As BRM is known to be involved in chemoresistance in cancer cells, this observation may be the likely explanation for ACC chemoresistance.

Keyphrases

genome wide
gene expression
dna damage
transcription factor
poor prognosis
copy number
binding protein
cancer stem cells