Branched-chain α-keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity.
Pinar Gumus BalikciogluCatherine Jachthuber TrubMetin BalikciogluOlga IlkayevaPhillip J WhiteMichael MuehlbauerJames R BainSarah ArmstrongMichael FreemarkPublished in: Endocrinology, diabetes & metabolism (2022)
BCKAs and glutamate/glutamine may serve as biomarkers of IR in adolescents with obesity, and uric acid might serve as a predictor of weight loss in response to lifestyle-intervention. Differential regulation of BCAA catabolism in adolescent males and females implicates critical roles for sex steroids in metabolic homeostasis.
Keyphrases
- weight loss
- uric acid
- metabolic syndrome
- young adults
- bariatric surgery
- roux en y gastric bypass
- gastric bypass
- randomized controlled trial
- physical activity
- insulin resistance
- mental health
- weight gain
- type diabetes
- glycemic control
- cardiovascular disease
- childhood cancer
- body mass index
- high fat diet induced
- obese patients
- skeletal muscle