Incidence and prognostic value of central nervous system involvement in infants with B-cell precursor acute lymphoblastic leukemia treated according to the MLL-Baby protocol.

Alexander M PopovGrigory TsaurZhan PermikinVeronika FominikhTatiana VerzhbitskayaTatiana RigerAnna DeminaEgor ShorikovAnatoly KustanovichLiudmila MovchanOlga StrenevaOlga KhlebnikovaOlga MakarovaOleg ArakaevAlexander SolodovnikovElmira BoichenkoKonstantin KondratchikNatalia PonomarevaElena LapotentovaOlga AleinikovaNatalia MiakovaGalina NovichkovaAlexander KarachunskiyLarisa Fechina

Published in: Pediatric blood & cancer (2022)

We can conclude that this combination of initial CNS involvement and MRD data can significantly improve risk-group allocation in future clinical trials enrolling infants with ALL.

Keyphrases

acute lymphoblastic leukemia
clinical trial
acute myeloid leukemia
randomized controlled trial
allogeneic hematopoietic stem cell transplantation
electronic health record
blood brain barrier
big data
machine learning
newly diagnosed