Increased Nociceptive Responses in Streptozotocin-Induced Diabetic Rats and the Related Expression of Spinal NR2B Subunit of N-Methyl-D-Aspartate Receptors.

Che Aishah Nazariah IsmailRapeah SuppianChe Badariah Abd AzizKhalilah HarisIdris Long

Published in: Diabetes & metabolism journal (2018)

We suggest that the pain process in the streptozotocin-induced diabetic rat that has been modulated is associated with the higher phosphorylation of the spinal NR2B expression in the development of PDN, which is similar to other models of neuropathic rats.

Keyphrases

diabetic rats
oxidative stress
poor prognosis
spinal cord
neuropathic pain
type diabetes
binding protein
high fat diet
spinal cord injury
long non coding rna
skeletal muscle
insulin resistance