Progesterone receptor membrane component 1 regulates lipid homeostasis and drives oncogenic signaling resulting in breast cancer progression.
Hannah AspergerNadia StammBerthold GierkeMichael PawlakUte HofmannUlrich M ZangerAnnamaria MartonRobert L KatonaAndrea BuhalaCsaba VizlerJan-Philipp CieslikEugen RuckhäberleDieter NiederacherTanja FehmTanja N FehmMarina LudescherPublished in: Breast cancer research : BCR (2020)
PGRMC1 may mediate proliferation and progression of breast cancer cells potentially by altering lipid metabolism and by activating key oncogenic signaling pathways, such as ERα expression and activation, as well as EGFR signaling. Our present study underlines the potential of PGRMC1 as a target for anti-cancer therapy.