Pharmacodynamic analysis of a fluid challenge with 4 ml kg-1 over 10 or 20 min: a multicenter cross-over randomized clinical trial.
Antonio MessinaChiara PalandriSilvia De RosaVinicio DanziEfrem BonaldiClaudia MontagniniSara BainoFederico VillaFrancesca SalaPaola ZitoKaterina NegriFrancesco Della CorteGianmaria CammarotaLaura SaderiGiovanni SotgiuManuel Ignacio Monge GarcíaMaurizio CecconiPublished in: Journal of clinical monitoring and computing (2021)
The infusion time of FC administration affects fluid responsiveness, being higher for FC10 as compared to FC20. The effect on flow variables of either FCs fades 5 min after the end of infusion.