Changes in cytokine and chemokine profiles in mouse serum and brain, and in human neural cells, upon tick-borne encephalitis virus infection.
Petra Pokorna FormanovaMartin PalusJiri SalatVaclav HönigMichal StefanikPavel SvobodaDaniel RuzekPublished in: Journal of neuroinflammation (2019)
Our results indicated that both neurons and astrocytes are potential sources of pro-inflammatory cytokines in TBEV-infected brain tissue. Infected/activated astrocytes produce cytokines/chemokines that stimulate the innate neuronal immune response, limiting virus replication, and increasing survival of infected neurons.
Keyphrases
- immune response
- resting state
- white matter
- spinal cord
- induced apoptosis
- cerebral ischemia
- endothelial cells
- cell cycle arrest
- functional connectivity
- drinking water
- dendritic cells
- multiple sclerosis
- oxidative stress
- endoplasmic reticulum stress
- anti inflammatory
- risk assessment
- induced pluripotent stem cells
- inflammatory response
- cell proliferation
- brain injury
- pluripotent stem cells
- blood brain barrier
- pi k akt
- cell death