Comparison of Near-Infrared Imaging Agents Targeting the PTPmu Tumor Biomarker.
Mette L JohansenJason VincentMarissa RoseAndrew E SloanSusann M Brady-KalnayPublished in: Molecular imaging and biology (2023)
The SBK2 PTPmu-targeting peptide conjugated to ICG specifically labels heterotopic human gliomas grown in mice between 10 min and 24 h following injection. Similar molecules constructed with more hydrophilic dyes demonstrated no specificity. These studies present a promising candidate for use in FIGS of PTPmu biomarker-expressing tumors.