Effect of antiseptic gels in the microbiologic colonization of the suture threads after oral surgery.
Samuel Rodríguez-ZorrillaAndrés Blanco CarriónAbel García-GarcíaPablo Galindo MorenoXabier Marichalar MendíaSeoane-Prado RafaelAntonio J Pérez EstévezMario Pérez-SayansPublished in: Scientific reports (2020)
Three different bioadhesive gels were evaluated in a double-blind randomized clinical trial in which microbial growth in the suture thread was assessed following post-surgical application of the aforementioned gels. Also assessed in this trial were, the intensity of post-surgical pain as well as the degree of healing of the patients' surgical wounds. A total of 21 patients (with 42 wisdom teeth) participated in this trial. Chlorhexidine gel, chlorhexidine-chitosan gel, and hyaluronic acid gel were evaluated, with a neutral water-based gel serving as the control agent. The aerobic and facultative anaerobic bacterial recovery on blood agar was lower in the placebo group than in the experimental groups. The most significant difference (p = 0.04) was observed in the chlorhexidine-chitosan group. in which the growth of Blood Agar and Mitis Salivarius Agar was significantly higher than in the placebo group. The intensity of post-surgical pain was very similar among all the groups. Significantly better healing rates were observed in the patients treated with chlorhexidine-chitosan gel when compared with those who used the placebo gel (p = 0.03), and in particular when compared with those patients who used hyaluronic acid gel (p = 0.01). Through our microbiological analyses, we were able to conclude that none of the bioadhesive gels tested resulted in beneficial reductions in the bacterial/fungal populations. However, the healing rates of patients who were treated with chlorhexidine-chitosan were better than those of the patients who used either the placebo gel or the hyaluronic acid gel.
Keyphrases
- hyaluronic acid
- phase iii
- clinical trial
- double blind
- surgical site infection
- microbial community
- chronic pain
- pain management
- minimally invasive
- randomized controlled trial
- study protocol
- drug delivery
- high intensity
- end stage renal disease
- ejection fraction
- neuropathic pain
- coronary artery bypass
- atrial fibrillation
- placebo controlled
- peritoneal dialysis
- acute coronary syndrome
- heavy metals