Adipocyte alterations in endometriosis: reduced numbers of stem cells and microRNA induced alterations in adipocyte metabolic gene expression.

Masoumeh Majidi ZolbinRamanaiah MamillapalliSepide E NematianTeddy G GoetzHugh S Taylor

Published in: Reproductive biology and endocrinology : RB&E (2019)

We demonstrate that microRNAs Let-7b and miR-342-3p affected metabolic gene expression significantly in adipocytes of women with endometriosis. Similarly, there is a reduction in the adipose stem cell population in a mouse model of endometriosis. Taken together these data suggest that endometriosis alters BMI in part through an effect on adipocytes and fat metabolism.

Keyphrases

adipose tissue
stem cells
gene expression
insulin resistance
mouse model
dna methylation
fatty acid
body mass index
high glucose
skeletal muscle
weight gain
machine learning
weight loss
artificial intelligence