Human umbilical cord/placenta mesenchymal stem cell conditioned medium attenuates intestinal fibrosis in vivo and in vitro.

Yoon Jeong ChoiWoo Ram KimDuk Hwan KimJee Hyun KimJun Hwan Yoo

Published in: Stem cell research & therapy (2024)

Human UC/PL-MSC-CM inhibits TGF-β1-induced fibrogenic activation in HIMFs by blocking the Rho/MRTF/SRF pathway and chronic DSS colitis-induced intestinal fibrosis. Thus, it may be regarded as a novel candidate for stem cell-based therapy of intestinal fibrosis.

Keyphrases

umbilical cord
mesenchymal stem cells
endothelial cells
high glucose
stem cells
diabetic rats
induced pluripotent stem cells
drug induced
pluripotent stem cells
bone marrow
cell therapy
oxidative stress
epithelial mesenchymal transition
signaling pathway
smooth muscle