Rapid cell division of Staphylococcus aureus during colonization of the human nose.
Anna K SzafrańskaVera JunkerMatthias SteglichUlrich NübelPublished in: BMC genomics (2019)
The cell division rates we determined were higher than the fastest documented rates during fulminant disease progression (in a mouse model of systemic infection) and much higher than those previously measured in expectorated sputum from cystic fibrosis patients. This paper supplies absolute in-vivo generation times for an important bacterial commensal, indicating that colonization of the human upper respiratory tract is characterized by a highly dynamic equilibrium between bacterial growth and removal.
Keyphrases
- cystic fibrosis
- endothelial cells
- respiratory tract
- staphylococcus aureus
- mouse model
- single cell
- end stage renal disease
- cell therapy
- induced pluripotent stem cells
- ejection fraction
- chronic kidney disease
- pseudomonas aeruginosa
- newly diagnosed
- mycobacterium tuberculosis
- pluripotent stem cells
- prognostic factors
- mesenchymal stem cells
- bone marrow
- pulmonary tuberculosis
- escherichia coli
- chronic obstructive pulmonary disease
- patient reported outcomes
- air pollution