Safety of combined ablative radiotherapy and immune checkpoint inhibitors in three phase I trials.

Connor LynchMark C KorpicsRohan R KatipallyChristine M BestvinaSean P PitrodaJyoti D PatelJason J LukeSteven J ChmuraAditya Juloori

Published in: European journal of cancer (Oxford, England : 1990) (2024)

This analysis features the largest prospectively evaluated cohort of patients treated with combination ablative SBRT and ICI to date and provides context for future trial design. We conclude that multi-site SBRT and ICI can be safely co-administered when SBRT is delivered with prioritization of normal tissue constraints.

Keyphrases

radiation therapy
radiation induced
locally advanced
clinical trial
study protocol
early stage
phase iii
current status
phase ii
randomized controlled trial
squamous cell carcinoma