SFPQ-ABL1-positive B-cell precursor acute lymphoblastic leukemias.
Andrea BiloglavLinda Olsson-ArvidssonJohan TheanderMikael BehrendtzAnders CastorBertil JohanssonPublished in: Genes, chromosomes & cancer (2020)
In recent years, a subgroup of B-cell precursor acute lymphoblastic leukemia (BCP ALL) without an established abnormality ("B-other") has been shown to be characterized by rearrangements of ABL1, ABL2, CSF1R, or PDGFRB (a.k.a. ABL-class genes). Using FISH with probes for these genes, we screened 55 pediatric and 50 adult B-other cases. Three (6%) of the adult but none of the childhood B-other cases were positive for ABL-class aberrations. RT-PCR and sequencing confirmed a rare SFPQ-ABL1 fusion in one adult B-other case with t(1;9)(p34;q34). Only six SFPQ-ABL1-positive BCP ALLs have been reported, present case included. A review of these shows that all harbored fusions between exon 9 of SFPQ and exon 4 of ABL1, that the fusion is typically found in adolescents/younger adults without hyperleukocytosis, and that IKZF1 deletions are recurrent. The few patients not treated with tyrosine kinase inhibitors (TKIs) and/or allogeneic stem cell transplantation relapsed, strengthening the notion that TKI should be added to the therapy of SFPQ-ABL1-positive BCP ALL.
Keyphrases
- chronic myeloid leukemia
- tyrosine kinase
- stem cell transplantation
- acute lymphoblastic leukemia
- epidermal growth factor receptor
- high dose
- end stage renal disease
- clinical trial
- newly diagnosed
- ejection fraction
- genome wide
- childhood cancer
- young adults
- stem cells
- acute myeloid leukemia
- gene expression
- chronic kidney disease
- low dose
- copy number
- liver failure
- randomized controlled trial
- physical activity
- small molecule
- diffuse large b cell lymphoma
- bone marrow
- acute respiratory distress syndrome
- single molecule
- multiple myeloma
- dna methylation
- allogeneic hematopoietic stem cell transplantation
- intensive care unit
- smoking cessation
- living cells
- extracorporeal membrane oxygenation
- genome wide identification
- study protocol
- fluorescent probe
- mechanical ventilation